TTC4, tetratricopeptide repeat domain 4, 7268

N. diseases: 32; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1096184
Disease: West Nile viral infection
West Nile viral infection 		0.010 GeneticVariation disease BEFREE Small Interfering RNA-Mediated Control of Virus Replication in the CNS Is Therapeutic and Enables Natural Immunity to West Nile Virus. 29606496 2018
CUI: C0523465
Disease: Serum albumin measurement
Serum albumin measurement 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 GeneticVariation group BEFREE Since aberrations in this region have been detected in malignant melanoma, we investigated DNA of paraffin-embedded sections from 16 typical naevi, 19 atypical naevi, 32 primary melanomas (15 superficial spreading melanomas, 17 nodular melanomas) and 25 metastases and DNA from four melanoma cell lines by PCR and direct sequencing analysis for mutations in all exons of TTC4. 11126369 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. 10639601 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model. 23695515 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE Comparisons of CNS-1 to 9L gliosarcoma tumor were made. 7760095 1994
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE We demonstrate that treatment with hsFlt3L leads to inhibition of tumor growth and significantly increased life span of animals implanted with syngeneic CNS-1 glioma cells. 15564139 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE TTC4, a novel candidate tumor suppressor gene at 1p31 is often mutated in malignant melanoma of the skin. 11126369 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 Biomarker group BEFREE To evaluate whether CpG-ODNs can induce rejection of established tumors, Lewis rats were inoculated intracerebrally with syngeneic CNS-1 glioma cells and subsequently injected with CpG-ODNs into the tumor bed. 10873101 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.070 AlteredExpression group BEFREE We also see increased TTC4 expression in a variety of tumour lines derived from other tissues. 18320024 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 GeneticVariation phenotype BEFREE Since aberrations in this region have been detected in malignant melanoma, we investigated DNA of paraffin-embedded sections from 16 typical naevi, 19 atypical naevi, 32 primary melanomas (15 superficial spreading melanomas, 17 nodular melanomas) and 25 metastases and DNA from four melanoma cell lines by PCR and direct sequencing analysis for mutations in all exons of TTC4. 11126369 2000
CUI: C0025202
Disease: melanoma
melanoma 		0.020 AlteredExpression disease LHGDN We show that TTC4 protein levels are raised in malignant melanoma cell lines compared to melanocytes. 18320024 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.020 GeneticVariation disease BEFREE The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma. 18320024 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE Our findings indicate that TTC4 may participate in the pathogenesis of malignant melanomas of the skin. 11126369 2000
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 GeneticVariation group BEFREE We now report the exon/intron structure of TTC4 and single strand conformation polymorphism (SSCP) analysis of DNA from 20 sporadic breast tumors. 10639601 2000
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE While immune checkpoint inhibitors (ICIs) have contributed to the development of therapeutic treatments for previously incurable advanced malignancies, they may induce immune-related adverse events (irAEs) in many organs including the CNS [1]. 31655267 2020
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.030 AlteredExpression disease BEFREE A preliminary screen of human breast cancer cell lines shows that TTC4 is expressed in all cases, but SSCP analysis of the coding region of this gene following RT-PCR failed to reveal any mutations. 9933562 1999
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.030 Biomarker disease BEFREE Other members of this gene family have been implicated in tumorigenesis suggesting that TTC4 may represent a breast cancer tumor suppressor gene. 10639601 2000
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.030 GeneticVariation disease BEFREE The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed point mutations in the TTC4 protein that may be associated with the progression of malignant melanoma. 18320024 2008
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease BEFREE Patients enrolled on Children's Cancer Group protocols 2861, 2891, 2941, and 2961 being treated for de novo AML were classified for the presence of CNS disease at diagnosis as CNS1 (<5 WBC in the CSF without blasts), CNS2 (<5 WBC in the CSF with blasts), or CNS3 (> or =5 WBC in the CSF with blasts). 20658610 2010
CUI: C4048329
Disease: Immunosuppression
Immunosuppression 		0.010 Biomarker disease BEFREE Liver transplantation is the only definitive therapy for CNS-I and is increasingly associated with excellent long-term survival but also incurs high costs, medical and surgical morbidities, and risks of immunosuppression. 31495946 2019
CUI: C0020433
Disease: Hyperbilirubinemia
Hyperbilirubinemia 		0.010 Biomarker disease BEFREE Despite consistent phototherapy, patients with CNS-I have worsening hyperbilirubinemia with advancing age. 31495946 2019
CUI: C0206726
Disease: gliosarcoma
gliosarcoma 		0.010 Biomarker disease BEFREE Comparisons of CNS-1 to 9L gliosarcoma tumor were made. 7760095 1994
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE Overexpression of a transmembrane isoform of neural cell adhesion molecule alters the invasiveness of rat CNS-1 glioma. 9581848 1998
CUI: C0017638
Disease: Glioma
Glioma 		0.030 Biomarker disease BEFREE To study the relationship between astrocytes and tumor cells, the CNS-1 rodent glioma cell line was used. 23695515 2013